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Research articles

Click here to read our latest research articles.

 

HDBuzz are a collaboration of scientists who write Huntington’s disease research news in plain language for the global HD community.
They have allowed us to retrieve their articles for the NSW ACT Huntington’s community.

 

Global research collaboration

The Huntington Study Group (HSG), is the world’s first HD cooperative therapeutic research organization. Today, HSG is a world leader in facilitating high quality clinical research trials and studies that bring us closer to finding more effective treatments for HD and reducing the burden of HD for families affected by the disease.

HSG is an organization of compassionate professionals dedicated to finding treatments that make a difference, providing rigorous care initiatives, and improving the quality of life and outcomes for HD families. How? By bringing together families, medical professionals, clinical researchers, HD advocacy groups, and sponsors to raise awareness of HD, share knowledge and best practices, and develop innovative treatments.

Words from HSG website.

How NSW contributes to research

More information coming soon.

 

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Caution urged for the use of gene-editing technology CRISPR

Published date: 12 August, 2020

A gene-editing tool known as CRISPR has been heralded as a breakthrough technology for scientists in the lab but also as a potential strategy to treat numerous genetic diseases, including Huntington’s. But a series of recent studies has suggested that CRISPR is less precise than previously thought, leading to unintended changes in the genome. Three ... Read more

HD and Histamines: Targeting Hybrid Receptors to Quiet Stressful Brain Talk

Published date: 15 July, 2020

Dopamine is an important chemical messenger in the brain that becomes imbalanced in Huntington’s disease. Researchers recently described a creative way to restore the balance and treat symptoms in HD mice, using an antihistamine drug that acts on hybrid dopamine receptors. It’s an innovative approach to HD therapeutics, but don’t start reaching for allergy meds ... Read more

Changing jobs: converting other cell types into neurons

Published date: 23 June, 2020

Researchers have known for quite some time that HD causes a progressive loss of neurons. But what if we could find a way to fill their place? In a new report, researchers used an intriguing strategy in living mice to do just that – they converted a different type of brain cell into neurons, with ... Read more

HD Young Adult Study defines the sweet spot: symptom-free with measurable changes

Published date: 27 May, 2020

A new study headed up by Dr. Sarah Tabrizi, a pioneer in HD research, assessed pre-manifest HD young adults many years from predicted symptom onset with a battery of clinical tests. The goal of this study was to identify a sweet spot – a time when HD participants weren’t experiencing any observable symptoms, but when ... Read more

Fountain of youth: HTT protein repairs neurons by maintaining youthful state

Published date: 13 May, 2020

A team of scientists has recently published their findings on how our bodies are able to repair brain and spinal cord injuries. They found that the huntingtin protein plays an important role in repairing damaged nerve cells. Repairing nervous system damage – the holy grail of medical science It has long been the ambition of ... Read more
Light and sleep

Light and Sleep

Published date: 7 April, 2020

Light & sleep Neurofilament Light Protein and Lifestyle Factors Commentary Words Dr Travis Cruickshank and Dr Danielle Bartlett

New molecule can reverse the Huntington's disease mutation in lab models

Published date: 6 April, 2020

A collaborative team of scientists from Canada and Japan have identified a small molecule which can change the CAG-repeat length in different lab models of Huntington’s disease. CAG repeats are unstable Huntington’s disease is caused by a stretch of C, A and G chemical letters in the Huntingtin gene, which are repeated over and over ... Read more

What does COVID-19 mean for Huntington’s disease families and HD research?

Published date: 6 April, 2020

COVID-19, short for coronavirus disease 2019, has taken the world by storm in almost every sense – many people have been infected with the SARS-CoV-2 virus, it’s created shopping pandemonium in stores, and many people are isolated at home. But behind that frenzied storm, scientists around the world have been working tirelessly to move research ... Read more

Huntington’s disease therapeutics conference 2020 – Day 1

Published date: 12 March, 2020

Our new writers Rachel Harding and Sarah Hernandez report from the Huntington’s Disease Therapeutics Conference – the biggest annual gathering of HD researchers.

THE LATEST HD SCIENCE

Published date: 4 March, 2020

Change to the design of Roche’s ongoing huntingtin lowering trial – known as the GENERATION HD1 study The pharmaceutical giant Roche ran an earlier, smaller, study with antisense oligonucleotides or ASOs as potential HD treatments. That was a safety study – designed to determine whether or not giving ASOs via the spinal fluid led to ... Read more