1800 244 735

Helpline (02) 9874 9777

Lighting the way: A new biomarker for Huntington’s disease

In Huntington’s disease, brain cells begin dying long before disease symptoms arise. Unfortunately, good tools for monitoring early brain changes – and testing whether new therapies slow or stop them – have not previously been available. However, a newly developed tool aiming to overcome this problem may mean big changes for the way we track Huntington’s disease.

Symptoms in Huntington’s disease are caused by the death of brain cells in specific parts of the brain. However, one of the curious features of the disease is that outward symptoms don’t typically appear until a good many brain cells have already died. Thus, there is a big disconnect between the timing of the brain changes and the outward symptoms of Huntington’s.

This disconnect makes early, proactive treatment of Huntington’s disease really important. To understand why, imagine Huntington’s as a fire burning inside a building. If no one calls the fire department until half the building is charred, so much of the building will be lost by the time the fire brigade arrives that no amount of effort will save it. In much the same way, waiting to treat Huntington’s disease until outward symptoms appear means allowing important brain cells to die – and once these cells die, they can’t be replaced.

Therefore, effectively treating Huntington’s disease will almost certainly require intervening before brain cell loss causes outward symptoms. Unfortunately, good tools for tracking brain changes early in Huntington’s don’t yet exist. This lack of tools is a problem, because it means that doctors and scientists are essentially blind to what’s going on in the brain early on in the disease.

Returning to our fire analogy, trying to treat Huntington’s disease while blind to early brain changes is like trying to fight a fire with your eyes closed. If you can’t see the fire, you don’t know if you are containing it – or if instead you have your water hose pointed in the wrong direction entirely. Similarly, if doctors are blind to early brain changes in Huntington’s disease, they can’t accurately tell if new therapies prevent or slow down these changes. This means that they must spend valuable time – time that individuals with the disease don’t have – waiting for outward symptoms to develop before determining if a treatment has any hope of working.

To avoid this waiting game, we are in urgent need of tools for tracking early brain changes in Huntington’s disease. Just like tools for monitoring the temperature of a fire provide important information about the status of the fire, tools for monitoring early brain changes in Huntington’s provide important information about the status of the disease.

Sign, Sign, Everywhere a Sign

In the clinic, such tracking tools are known as “biomarkers”. Biomarkers give signs or signals of what’s going on in diseases like Huntington’s. They can be any kind of test – running the gamut from from blood tests to thinking tests to brain scans and everything in between – but they all have one thing in common: they measure something concrete about the disease. A good biomarker lets us monitor the status of the disease, which is important for predicting progression or telling if a treatment is working.

In a practical sense, therefore, biomarkers are really important for the Huntington’s community because they can make clinical trials of new drugs quicker and more reliable. Having good biomarkers would be a powerful weapon in the fight against Huntington’s disease.

A Biomarker for PDE10

Fortunately, a good biomarker of early brain changes in Huntington’s disease may be just over the horizon.

The new biomarker is focused on PDE10 – a brain protein that has already made a splash in the Huntington’s research community. Scientists think that PDE10 helps brain cells communicate with one another and that it might be a good drug target for the disease. In animals, PDE10-targeting drugs improve brain cell survival and delay the onset of Huntington’s-like symptoms. In the clinic, an ongoing trial currently recruiting subjects is now testing whether PDE10-targeting drugs improve symptoms in humans with HD.

Two features make PDE10 particularly well suited as a biomarker for Huntington’s disease. First, it is found almost exclusively in parts of the brain where brain cells die in Huntington’s disease. As a biomarker, therefore, it would give information specifically about problem areas in the disease. Second, although these brain cells normally make a lot of PDE10, they start making less and less long before they die in Huntington’s. Thus, a PDE10 biomarker would provide information on brain cells that are sick but not yet dead.

Together, these two pieces of information would give PDE10 the potential to be a really powerful biomarker – one that would allow doctors to specifically monitor the health of at-risk brain cells in Huntington’s disease before outward symptoms develop.

Glow, Little Biomarker, Glow

With this idea in mind, scientists at Pfizer created a PDE10 biomarker for tracking early brain changes in Huntington’s disease.

In essence, the new biomarker is a picky, sticky substance that attaches tightly PDE10 but not other proteins in the body. Importantly, this picky, sticky substance has tiny glowing bits attached to it. Though tiny, these glowing bits are a big addition: they let scientists using a special camera track the substance wherever it goes. The substance itself is safe, so scientists can administer it to individuals with Huntington’s disease – and then watch where it travels inside the human body.

Most of the new biomarker ends up stuck to PDE10 in brain cells, which means that it accumulates in exactly the brain areas that we want to watch in Huntington’s disease. In these areas, healthy cells (with lots of PDE10) glow brighter than sick cells (with only a little PDE10) in danger of dying. By measuring the brightness of the glowing biomarker with a special camera, therefore, scientists can monitor the health of these at-risk brain cells over time.

Putting It to the Test

Pfizer scientists put this new tool to a practical test in a study published in the Journal of the American Medical Association.

In their study, the scientists took pictures of Huntington’s-vulnerable brain regions lit up by their new glowing biomarker, and then they looked closely at the pictures to see if the regions looked different in individuals with and without early Huntington’s disease. Importantly, the Huntington’s individuals in this study had very early disease: they either only mild symptoms or no symptoms at all.

When the scientists analyzed the pictures, they found that the brain regions from the different groups of subjects in fact looked very different – even though there were not obvious differences in outward symptoms between subjects with and without Huntington’s disease. Specifically, for important brain regions, the glow coming from the PDE10 biomarker was brighter in healthy volunteers than individuals with Huntington’s disease. Further, even among Huntington’s individuals, the glow in those with no outward symptoms was brighter than that in those with mildly symptomatic disease.

Thus, there was a strong relationship between the brightness of the new PDE10 biomarker and the extent of Huntington’s disease. This relationship was much stronger than what scientists could detect using existing tools.

Based on these results, the scientists believe that their new biomarker is sensitive to early brain changes in Huntington’s disease.

How Does This Help Us?

The PDE10 biomarker could be a really powerful tool for the Huntington’s community, because it offers an easy, accurate way to monitor brain changes early in the disease. Better disease monitoring makes assessing if a potential treatment is working both easier and more accurate, which speeds up clinical trials. Thus, even though the biomarker itself is not a treatment, it may directly improve and accelerate the search for new Huntington’s therapies.

Further, this biomarker could allow doctors to predict when an individual with pre-symptomatic Huntington’s will begin to experience symptomatic disease. This prediction would be invaluable both for clinical studies (where it is important to test therapies in patients whose exact disease status is known) and for individuals living in the shadow of looming symptomatic disease.

The Bottom Line

It is encouraging to see a large, well-resourced pharmaceutical company invested in running efficient, effective clinical trials for Huntington’s disease. Although the Pfizer scientists must do more work to verify their new biomarker’s sensitivity, the potential benefits of this new tool in the search for Huntington’s therapies are clear. Across the board, the development and validation of good biomarkers will speed the search for effective treatment.

Share on facebook
Share on twitter
Share on pinterest
Share on email

Latest Research Articles

Scientists identify precisely how pridopidine works in models of Huntington’s disease

Published date: 12 June, 2021

Pridopidine is a drug developed to treat Huntington’s disease (HD) and now scientists have a clearer understanding of how it works in the body and brain. In a series of academic papers, researchers figured out that pridopidine is working by targeting a particular receptor protein called S1R. With this new understanding, the researchers believe pridopidine ... Read more

Huntington's disease therapeutics conference 2021 – Day 3

Published date: 29 April, 2021

We are back for the last day of the virtual 2021 CHDI Therapeutics conference. This article summarises our live Twitter updates on the exciting science being presented, which you can find with the hashtag #HDTC2021. The final session of the conference will provide the latest news on more Huntington’s disease clinical programs. A new way ... Read more

Huntington's disease therapeutics conference 2021 – Day 2

Published date: 28 April, 2021

We are back with Day 2 of the virtual 2021 CHDI Therapeutics conference. This article summarises our live Twitter updates on the exciting science being presented, which you can continue to follow with the hashtag #HDTC2021. The morning session focussed on promising HD therapeutics that are in preclinical development and the afternoon session covered different ... Read more

Huntington’s disease therapeutics conference 2021 – Day 1

Published date: 28 April, 2021

The CHDI Therapeutics Conference 2021 kicked off today. This article summarizes our live Twitter updates on the exciting science being presented, which you can continue to follow with the hashtag #HDTC2021. The morning of Day 1 focused on clinical trial updates, while the afternoon explored genetic modifiers of HD and how they might be harnessed ... Read more

Huntington’s disease clinical trial round up

Published date: 26 April, 2021

It seems like the HD community has been inundated with updates from different companies and clinical trials recently. The news is far from complete doom and gloom; although there have been some real disappointments from some of the frontrunner trials, there are also positive updates from many different companies and lots of reasons for us ... Read more

Good news from uniQure: gene therapy trial on track, and promising data in animals

Published date: 15 April, 2021

Two recent press releases from uniQure provide welcome good news: the first ever HD gene therapy, known as AMT-130, has been administered via brain surgery to a small set of participants in an early safety trial. At the same time, uniQure has published findings in HD animal models that increase confidence in the drug’s ability ... Read more