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Research articles

Click on this link to read our latest research articles.

Click on this link to find out more about Huntington’s NSW ACT Research grant opportunities.

HD Buzz

HDBuzz is a collaboration of scientists who write Huntington’s disease research news in plain language for the global HD community. They have allowed us to retrieve their articles for the NSW ACT Huntington’s community.

Westmead HD Outreach Service

The Outreach Service is part of a multidisciplinary team of medical, nursing and allied health services which provides review, intervention, treatment, case management, counselling, support, education and management of problems and issues associated with Huntington’s for patients, their families and carers. In addition to this care, the service has been involved in local and major international research studies since its establishment at Westmead Hospital in 1995. Hundreds of volunteers have generously participated in research to better understand the disease and in the search for effective treatments.

Westmead Hospital is a HSG Credential Research Site. Professor Clement Loy is the Principal Investigator for this site.

Global research collaboration

The Huntington Study Group (HSG) is the world’s first HD cooperative therapeutic research organization. Today, HSG is a world leader in facilitating high quality clinical research trials and studies that bring us closer to finding more effective treatments for HD and reducing the burden of HD for families affected by the disease.

HSG is an organization of compassionate professionals dedicated to finding treatments that make a difference, providing rigorous care initiatives, and improving the quality of life and outcomes for HD families. They bring together families, medical professionals, clinical researchers, HD advocacy groups, and sponsors to raise awareness of HD, share knowledge and best practices, and develop innovative treatments.

Enroll-HD

Enroll-HD is a clinical research platform and the world’s largest observational study for Huntington’s disease families. It is a resource for the entire HD community, including families, clinicians, researchers, advocates, and anyone else who has a connection to or an interest in HD.

Huntington’s Disease Network of Australia

The Huntington’s Disease Network of Australia (HDNA) is a project conceived by Professor Julie Stout of Monash University. Formed in 2020 to coordinate efforts that enhance care and services for HD and prepare for the advent of new HD treatments. The Map-HD Registry is for people in Australia who are affected by HD. All family members or people affected by HD are encouraged to register, whether or not they are at risk themselves.
 
 

          Huntington's Disease Network of Australia

Stem cells and HD: past, present and future

Published date: 8 August, 2011

Everyone’s heard of stem cells, but so far, stem cell treatments for Huntington’s disease have disappointed. Scientists can now create stem cells from skin samples – and even cut out the middle man to make brain cells directly. Stem cell treatments are still a long way off, but these cells are already accelerating HD research ... Read more

Coming soon from the HD World Congress: Oz Buzz!

Published date: 1 August, 2011

This September, your HDBuzz editors Jeff Carroll and Ed Wild will be teaming up with Emmy award-winning broadcaster Charles Sabine to bring you ‘Oz Buzz’ – the hottest science news from the World Congress on Huntington’s Disease in Melbourne, Australia – September 11-14, 2011. The World Congress on Huntington’s Disease The World Congress on Huntington’s ... Read more

Therapeutics conference videos now online

Published date: 26 July, 2011

HDBuzz covered CHDI’s therapeutics conference in February 2011 from Palm Springs. Now, videos of many of the scientific presentations have been made available to watch online. The therapeutics conference The annual Huntington’s disease Therapeutics Conference, hosted by CHDI Foundation Inc., is a unique forum for HD researchers to come together, share exciting findings, and establish ... Read more

Cut-and-paste DNA: fixing mutations with 'genome editing'

Published date: 18 July, 2011

What if we could edit the DNA of patients to remove the Huntington’s disease mutation altogether? Sounds like science fiction, but new research in an animal model of hemophilia suggests that it can work – and now HD researchers are on the case. DNA, RNA and protein Every case of Huntington’s disease is caused by ... Read more

Caffeine, cannabis and caution

Published date: 6 July, 2011

Recent news stories suggest that Caffeine might be harmful to people with the Huntington’s disease mutation, while others claim that Cannabis might be helpful. Here’s the lowdown on the science behind these stories, and why we think that a third ‘C’ – Caution – might be the best medicine when it comes to news stories ... Read more

Re-routing the huntingtin protein inside cells

Published date: 26 June, 2011

The mutant huntingtin protein causes Huntington’s disease, but not all mutant huntingtin is equally toxic. Exactly where it’s found inside cells has a major impact on whether cells can deal with the mutant protein. New research is helping understand the signals that move mutant huntingtin around the cell, provides clues about how to make it ... Read more

Not all in your head: digestive problems in HD

Published date: 18 June, 2011

Weight loss is a common symptom in Huntington’s disease, and one that remains unexplained. Now, by studying the digestive systems of HD mice – and paying close attention to their droppings – researchers have unearthed a clue to weight loss in HD. Weight loss in HD Weight loss is a familiar symptom of Huntington’s disease, ... Read more

Huntexil update: EMA asks for further trial

Published date: 6 June, 2011

In April, the American drug regulator told NeuroSearch it would need a further large clinical trial before its Huntington’s disease symptom-control drug Huntexil would be licensed. Now the European regulator, the EMA, has said the same for European licensing. The EMA’s advice NeuroSearch, the Danish drug company developing Huntexil, has received advice from the European ... Read more

KMO inhibitor drug improves lifespan of Huntington's disease mice

Published date: 2 June, 2011

An enzyme called KMO, which alters the balance of harmful and protective brain chemicals, has been a focus of research into possible Huntington’s disease treatments for several years. Now, the first positive results of a KMO inhibiting drug have been published in the scientific journal Cell. HDBuzz investigates… Quin and Kyna – a classic tale ... Read more

Meet the enemy: neutron ray reveals HD protein structure

Published date: 26 May, 2011

The mutant huntingtin protein forms clumps, or aggregates, in brain cells. Many scientists believe these clumps contribute to the death of these cells and symptoms in HD. Now scientists have used a beam of neutrons to study the earliest structures formed in these aggregates. Huntington’s, Huntington, Huntingtin… The words used to describe Huntington’s Disease can ... Read more