1800 244 735

Helpline (02) 9874 9777

HDBuzz Special Feature: Huntington's disease and sleep

Many Huntington’s disease patients have problems with sleep and in the control of daily or ‘circadian’ rhythms. These problems may actually be part of the range of symptoms in HD, and managing or treating them directly may be beneficial. In this special HDBuzz feature, sleep expert Prof Jenny Morton looks at the science behind sleep problems and solutions in Huntington’s disease. Coming soon, part 2: Prof Morton’s ‘Simple Rules for a Good Night’s Sleep’.

After a long day, many of us look forward to the bliss that comes with a good night’s sleep. But not everyone who is tired is guaranteed a peaceful night’s sleep. For those to whom sleep does not come, the night can seem a lonely and sometimes anguished exile. And more often than not, those who live with the sleepless share the burden. Unfortunately for the person with a neurological disease like Huntington’s, the consequences of sleep disturbance may not only be distressing and disruptive, but may also contribute significantly to their symptoms.

We all need sleep

There is no doubt that sleep is an essential and beneficial part of a daily pattern of life. Short-term sleep deprivation causes no lasting damage, but unquestionably impacts mood. Without adequate sleep, people become irritable and unable to sustain attention. They also become unreasonable and short-tempered.

Most people can bounce back after a couple of good night’s sleep. But what if you have Huntington’s disease?

Evidence is emerging that HD patients frequently suffer from abnormalities in both sleep and in the control of daily or ‘circadian’ rhythms. It is possible that sleep and circadian dysfunction may actually be part of the range of symptoms in HD. If this is the case, it is important that it is recognized, because sleep and circadian disturbances have negative impact on people’s daily lives, even in people without a neurological problem. So, sleep and circadian disturbance in HD patients are likely to contribute to HD symptoms that are worsened by sleep deprivation, such as irritability and anxiety.

Chances are, if you have Huntington’s disease and sleep poorly, it will not be solely due to your disease. A significant percentage of the general population suffers sleep disruption due to personal habits, lifestyle or environment. We stay up too late – we get up too early. We take drugs that interfere with sleep, we over-stimulate ourselves with late-night activities such as work or television. HD patients are no exception to this. The difference is that HD patients may not have the reserves that allow a neurologically healthy person to cope with sleep deprivation.

Chronic sleep deprivation is damaging to health in normal people, so it’s possible that chronic sleep-wake deficits could actually contribute to mental decline in HD. If this is the case, then treating sleep deficits might delay cognitive and emotional decline in HD.

Is there a difference between sleep and circadian rhythms?

Circadian rhythms and sleep are two different processes, although the terms are often used interchangeably. Circadian rhythms are biological processes that change roughly every 24 hours. They are orchestrated by a small part of the brain known as the suprachiasmatic nucleus or SCN. The SCN is known as the body’s ‘master clock’. It regulates all your daily activities, including when you wake up and when you want to go to bed.

Sleep is a very obvious ‘circadian behavior’, because the onset of sleep typically happens once a day. But it is just one of many circadian behaviors that are controlled by the master clock. Others include heart rate, hormone secretion, blood pressure and body temperature.

So, sleep is a circadian behavior that is influenced by the SCN, but it is not generated there. Sleep is a very complex thing, and the process of going to sleep, maintaining sleep and waking up are all controlled by different parts of the brain.

There are multiple stages of sleep that can be identified by looking at the brain’s electrical activity. The mechanisms that generate sleep and control movement between these different sleep stages are not fully understood. It is not even known why we sleep, although there is growing evidence that sleep is important for learning and forming lasting memories. We may even do some ‘brain housework’ while we sleep – by reviewing experiences that have occurred during the day.

Neurological disease causes sleep problems

Sleep abnormalities and disorders of circadian rhythm are already recognized as symptoms in a number of other neurodegenerative diseases, particularly Parkinson’s disease and Alzheimer’s disease. In fact, sleep disruption in Alzheimer’s patients is reportedly the main reason for their institutionalization. This is probably because when an Alzheimer’s patient has disrupted sleep, this becomes a problem not only for the patient, but also for their carer.

More research is needed before we will know if sleep or circadian rhythm disruption is part of the complex repertoire of Huntington’s disease symptoms, or if it is just a ‘knock-on’ effect of having HD. But whatever the cause, we should recognize that even mild sleep abnormalities could worsen neurological symptoms in HD patients. Knock-on effects of sleep abnormalities in HD may be critical for determining the care-plan of patients. And, if they worsen thinking and mood disturbances, they may also end up having a have greater impact on quality of life than other symptoms like involuntary movements.

Circadian abnormalities in Huntington’s disease

The first clue that sleep or circadian rhythms might be abnormal in HD patients came from a study showing subtle changes in circadian activity profiles, measured by wrist-mounted movement monitors.

Circadian rhythms are difficult to measure accurately in humans, because the rhythm can be masked by other activities such as work and social life. But they are easy to measure in mice, and direct measurement of circadian rhythms in one HD mouse model showed clear abnormalities in circadian behavior.

These mice showed a progressive disintegration of the normal rhythm of rest and activity. That disturbance was mirrored in the HD patients wearing the activity monitors. In the HD mice, there was also disruption in activity levels of genes that controlled the circadian clock in the SCN. These circadian abnormalities in HD mice have now been confirmed by three different laboratories.

Importantly, the breakdown in circadian rhythms in the mice were linked to their decline in thinking function – and restoring good circadian rhythms delayed the thinking decline.

This suggests that some of the thinking problems in the mice were caused by the disruption of sleep and circadian rhythm. If the same thing happens in humans, then improving sleep and circadian function might have a beneficial effect on cognitive and emotional problems in people with Huntington’s disease.

What causes sleep disturbance in Huntington’s disease?

The most common causes of sleep disturbance in healthy people are depression, stimulant drugs like caffeine and nicotine, and disruptive lifestyles like going to bed late, getting up late and taking naps during the day. So, it is likely that these same culprits are responsible for some sleep disturbance in Huntington’s disease patients.

But it’s also possible that sleep and circadian abnormalities are direct symptoms of HD, in the same way that chorea is a symptom. There is evidence for sleep disturbance in early symptomatic HD patients who are not taking any medication and not depressed.

So, we don’t know yet if there are sleep and circadian abnormalities that are caused directly by the HD mutation, or if it is simply that some patients have disrupted sleep and circadian behavior because they have symptoms of HD.

More research is needed to address this question. But it is interesting that many of the subtle symptoms of early HD are similar to those experienced by normal individuals after sleep deprivation.

Can we treat sleep or circadian disturbances in HD?

If you have Huntington’s disease, you don’t want to add the consequences of sleep deprivation to your symptomatic burden. But there is good news: there are already well-established treatments for sleep disturbance.

If disrupted sleep is interfering with your daily life, you should talk to your doctor. He or she may be able to prescribe a drug treatment that will help you. This does not have to be a long-term treatment – sometimes a short period of treatment is enough to help you re-establish good sleeping patterns.

If you think you might be depressed, you should also talk to your doctor about depression and sleep problems. Depression is the enemy of sleep, but effective treatments are available.

Remember, too, that many medications that can cause sleeplessness as a side effect. Ask your doctor or pharmacist if the medication you are taking can lead to sleeplessness. Don’t stop taking the medication, even if you think it might be interfering with your sleep. Always seek the advice of your physician and other healthcare professionals before changing your medications.

Simple Rules For a Good Night’s Sleep

As well as drug treatments, there are recognized, scientifically sound self-help strategies for improving sleep. Whether you are a carer or a patient, improving your sleep hygiene can only be beneficial.

Prof Morton’s ‘Simple Rules For a Good Night’s Sleep’, were recently published in the journal Experimental Neurology. In the next installment of this special feature on sleep in Huntington’s disease, we’ll bring you her ‘Simple Rules’ in full.

Latest Research Articles

Disappointing news from Novartis about branaplam and the VIBRANT-HD trial

Published date: 9 December, 2022

The pharmaceutical company Novartis has released a community update which announces that they are ending development of branaplam, a huntingtin lowering drug, for possible treatment in Huntington’s disease (HD). This news comes following recent bad news about side effects of branaplam in HD patients, being tested in the VIBRANT-HD clinical trial, dosing of which was ... Read more

Update on the PTC Therapeutics PIVOT-HD Trial

Published date: 2 November, 2022

Recruitment of participants into the US arm of the PTC Therapeutics PIVOT-HD trial has been paused. Since this announcement, there have been a lot of different (and confusing!) headlines about the pause in recruitment. In this article, we will lay out what is going on and what this announcement means. What is the aim of ... Read more

Forward momentum for Roche and Wave in latest news about huntingtin-lowering trials

Published date: 30 September, 2022

In the past week or so, during and following a big HD research conference, two companies developing medicines for Huntington’s disease announced news about their huntingtin-lowering drugs. First, the pharmaceutical company Roche announced plans for a new clinical trial of tominersen. Then, the genetic medicines company Wave Life Sciences shared early data showing that its ... Read more

Focusing in on fibrils; scientists give us a glimpse of huntingtin protein clumps

Published date: 8 September, 2022

A group of scientists from the EPFL in Lausanne, Switzerland have published a paper in the Journal of the American Chemical Society, describing clumps made up of a fragment of the huntingtin protein. A word that’s commonly used to describe these is “aggregates.” Using very powerful microscopes, the team was able to zoom in and ... Read more

Hereditary Disease Foundation (HDF) conference 2022 – Day 4

Published date: 2 September, 2022

DNA repair and CAG repeat instability The effect of HTT lowering on CAG repeat expansions Welcome to last day of the @hdfcures conference! We’ll only be sharing a few talks from today’s sessions, which focus on DNA repair. The first is from HDBuzz’s very own Jeff Carroll! Jeff will be sharing his work on HTT ... Read more

Hereditary Disease Foundation (HDF) conference 2022 – Day 3

Published date: 1 September, 2022

Pre-clinical work moving toward trials New tools to lower HTT showing promise in animal models Welcome back! The first talk we will be tweeting about today is from Anastasia Khvorova, who will be telling us about her teams work on lowering of Huntingtin using technology called RNAi. One of the problems in studying drug delivery ... Read more